Table 3.

The modified neurologic severity score (mNSS).

Methods	Purpose	Timepoint	Apparatus	Measurement index	Range of normal value
1. Abnormal movements or absence of reflex	Assessment of neurologic impairment on reflex and abnormal movements	One day prior to surgery, D1, D3, D7, D14, D30 after surgery (106)	None required	Corneal reflex, pinna reflex, startle reflex, and dystonia or convulsion	0 point in both mice and rats (105)
2. Beam balance test	Assessment of neurologic impairment on coordination of movements	One day prior to surgery, D1, D3, D7, D14, D30 after surgery (106)	Wooden cylindrical bar (107)	The time that stays on the balance beam	0 point in both mice and rats (105)
3. Sensory function	Assessment of neurologic impairment on sensory function	One day prior to surgery, D1, D3, D7, D14, D30 after surgery (106)	A table	Contractile reaction	0 point in both mice and rats (105)
4. Locomotor function	Assessment of neurologic impairment on locomotor function	One day prior to surgery, D1, D3, D7, D14, D30 after surgery (106)	None required	The state of the motor function	0 point in both mice and rats (105)