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. 2021 Jun 17;12:687416. doi: 10.3389/fpls.2021.687416

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Copyright © 2021 Yamaguchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the function of H3K27me3 demethylases in gene regulation. (A) REF6 demethylates H3K27me1/2/3 via recognition of CTCTGYTY (where Y is C or T) DNA motifs. (B) JMJ13 recognizes H3K27me3 marks. (C) JMJ proteins interact with transcription factors and are recruited to their target sites. (D) REF6 interacts with BRAHMA (BRM) and mediates nucleosome positioning. (E) REF6 prevents the uncontrolled spreading of PRC2-mediated chromatin silencing. (F) DNA methylation at CTCTGYTY motifs prevents REF6 targeting. H3K27me3, pink triangles; H3K9ac, light blue circles; DNA methylation, gray circles.