Table 2. Demographic and clinical characteristics of the short-term (< 14 days) and the long-term (≥ 14 days) BTT groups at the time of transplantation.
| Short-term (n = 21) | Long-term (n = 20) | P-value | |
|---|---|---|---|
| Age, years, median (IQR) | 60 (48–63) | 51 (39–57) | 0.053 |
| Male, n (%) | 13 (61.9) | 13 (65.0) | 0.837 |
| BMI, kg/m2, median (IQR) | 22.6 (20.7–24.8) | 23.1 (19.9–26.1) | 0.876 |
| Blood type, n (%) | 0.333 | ||
| A | 7 (33.3) | 10 (50.0) | |
| B | 5 (23.8) | 6 (30.0) | |
| O | 4 (19.0) | 3 (15.0) | |
| AB | 5 (23.8) | 1 (5.0) | |
| Diagnosis, n (%) | 0.286 | ||
| Interstitial lung disease | 16 (76.2) | 14 (70.0) | |
| Bronchiolitis obliterans syndromea | 1 (4.8) | 1 (5.0) | |
| Pulmonary vascular disease | 0 (0.0) | 3 (15.0) | |
| Others | 4 (19.0) | 2 (10.0) | |
| SAPS II, median (IQR) | 34 (33–40) | 36 (29–56) | 0.666 |
| Type of transplantation, n (%) | 0.410 | ||
| Double lung | 19 (90.5) | 16 (80.0) | |
| Heart-lung | 2 (9.5) | 4 (20.0) | |
| Mechanical ventilation, n (%) | 0.056 | ||
| Not required | 1 (4.8) | 0 (0.0) | |
| Intubated | 8 (38.1) | 2 (10.0) | |
| Tracheostomized | 12 (57.1) | 18 (90.0) | |
| Mobilization, n (%) | 17 (81.0) | 14 (70.0) | 0.484 |
| Initial configuration, n (%) | 0.093 | ||
| Veno-venous | 20 (95.2) | 15 (75.0) | |
| Veno-arterial | 1 (4.8) | 5 (25.0) | |
| Configuration at transplantation, n (%) | 0.031 | ||
| Veno-venous | 18 (85.7) | 11 (55.0) | |
| Veno-arterial | 3 (14.3) | 9 (45.0) | |
| Configuration change, n (%) | 5 (23.8) | 10 (50.0) | 0.082 |
| Time to ECMO initiation, days, median (IQR) | |||
| From hospital admission | 10 (4–25) | 15 (5–27) | 0.513 |
| From ICU admission | 2 (0–10) | 3 (0–11) | 0.821 |
| Time to lung transplantation, days, median (IQR) | |||
| From hospital admission | 15 (10–32) | 40 (28–50) | 0.001 |
| From ICU admission | 11 (8–16) | 29 (18–39) | <0.001 |
| From ECMO initiation | 8 (3–11) | 19 (14–31) | <0.001 |
| Complications during bridging, n (%) | |||
| Bleeding complications | 3 (14.3) | 10 (50.0) | 0.014 |
| Thrombotic complications | 3 (14.3) | 6 (30.0) | 0.277 |
| Renal replacement therapy | 2 (9.5) | 3 (15.0) | 0.663 |
| Transfusion, units, median (IQR) | |||
| Red blood cell | 3 (2–12) | 15 (9–22) | 0.001 |
| Platelet | 0 (0–2) | 0 (0–9) | 0.134 |
| Fresh frozen plasma | 0 (0–8) | 21 (0–59) | 0.013 |
| Cryoprecipitate | 0 (0–0) | 0 (0–5) | 0.235 |
| Ischemic time, h, median (IQR) | 4.1 (4.0–4.4) | 4.3 (3.8–4.9) | 0.359 |
| Primary graft dysfunction at 72 hours, n (%) | 0.716 | ||
| Grade 0 or 1 | 6 (28.6) | 6 (25.0) | |
| Grade 2 | 11 (52.4) | 9 (45.0) | |
| Grade 3 | 4 (19.0) | 6 (30.0) | |
| AKI requiring dialysis, n (%) | 4 (19.0) | 7 (35.0) | 0.249 |
| Hypotension requiring vasopressors for > 24 hours, n (%) | 5 (23.8) | 7 (35.0) | 0.431 |
AKI, acute kidney injury; BMI, body mass index; BTT, bridge to lung transplantation; ECMO, extracorporeal membrane oxygenation; IQR, interquartile range; SAPS II, simplified acute physiologic score II.
aSecondary to the previously treated hematologic malignancies.