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. 2021 Jun 17;11:663756. doi: 10.3389/fcimb.2021.663756

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Copyright © 2021 Cai, Lin, Hu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The 3D-PCoA plot based on Jaccard distance matrix (p<0.001, PERMANOVA) illustrates the beta diversity of oral microbiota. PD (periodontitis, red spots), HC (healthy control, blue spots). (B) The taxonomic bar plots on the phylum level. Each column represents a sample (HC left and PD right), and each small fragment in different colors represents different phyla. (C) The pie charts demonstrate the difference of microbial composition between HC (left) and PD (right) on the phylum level. Different colors correspond to the phyla on the list. (D) The subcategories composition of four phyla. Each pair of pie charts shows the comparison of microbial abundance between HC and PD on the genus level (*p < 0.05; **p < 0.01; ***p < 0.001, tested by RNA-seq methods, algorithm: edgeR).