Table 4.
Significant functions and pathways on L2 and L3 compared with periodontitis and healthy groups.
| Variables (L2) | log2FC | LogCPM | P values | FDR |
|---|---|---|---|---|
| Cell Motility | 0.3819 | 14.092 | <0.001 | <0.001 |
| Environmental Adaptation | 0.10176 | 10.496 | <0.001 | <0.01 |
| Signal Transduction | 0.087304 | 13.795 | <0.001 | <0.01 |
| Metabolism of Terpenoids and Polyketides | -0.02687 | 14.146 | <0.001 | <0.01 |
| Metabolism of Cofactors and Vitamins | -0.02879 | 15.525 | <0.001 | <0.01 |
| Folding, Sorting and Degradation | -0.02063 | 14.726 | <0.001 | <0.01 |
| Cellular Processes and Signaling | -0.0408 | 15.158 | <0.01 | <0.05 |
| Nervous System | -0.07875 | 9.5907 | <0.01 | <0.05 |
| Variables (L2) | log2FC | LogCPM | P values | FDR |
| Bacterial motility proteins | 0.40809 | 13.024 | <0.001 | <0.001 |
| Bacterial chemotaxis | 0.48527 | 11.742 | <0.001 | <0.001 |
| Methane metabolism | 0.088374 | 13.439 | <0.001 | <0.001 |
| Flagellar assembly | 0.58686 | 11.586 | <0.001 | <0.001 |
| Ether lipid metabolism | 0.56359 | 5.9541 | <0.001 | <0.001 |
| Other ion-coupled transporters | -0.060619 | 13.597 | <0.001 | <0.001 |
| Xylene degradation | 0.28929 | 8.4607 | <0.001 | <0.01 |
| Pentose and glucuronate interconversions | 0.11254 | 11.654 | <0.001 | <0.01 |
| Carotenoid biosynthesis | -0.43936 | 6.6335 | <0.001 | <0.01 |
| Ubiquitin system | -0.40326 | 7.6626 | <0.001 | <0.01 |
| Nitrogen metabolism | -0.040959 | 12.795 | <0.001 | <0.01 |
| Insulin signaling pathway | 0.082719 | 9.7838 | <0.001 | <0.01 |
| D-Arginine and D-ornithine metabolism | -0.29459 | 5.8248 | <0.001 | <0.01 |
| Base excision repair | -0.046719 | 12.258 | <0.001 | <0.01 |
| Sulfur metabolism | -0.12471 | 11.39 | <0.01 | <0.05 |
| Polycyclic aromatic hydrocarbon degradation | -0.077289 | 10.401 | <0.01 | <0.05 |
| Tyrosine metabolism | -0.056456 | 11.869 | <0.01 | <0.05 |
| Synthesis and degradation of ketone bodies | 0.20517 | 9.0478 | <0.01 | <0.05 |
| Histidine metabolism | 0.053466 | 12.395 | <0.01 | <0.05 |
| Linoleic acid metabolism | 0.16046 | 8.5719 | <0.01 | <0.05 |
| Chloroalkane and chloroalkene degradation | 0.090688 | 10.423 | <0.01 | <0.05 |
| Carbon fixation pathways in prokaryotes | 0.034009 | 13.338 | <0.01 | <0.05 |
| Primary immunodeficiency | -0.070153 | 9.19 | <0.01 | <0.05 |
| Glycine, serine, and threonine metabolism | 0.0204 | 13.083 | <0.01 | <0.05 |
| Type I diabetes mellitus | -0.05003 | 9.2339 | <0.01 | <0.05 |
Log2FC (log2 fold change) represents the ratio of two groups (PD vs. HC) based log2.
LogCPM (log counts per million) represents the expression level of variables.
FDR is the false discovery rate as correction of P value.