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. 2021 Jun 15;12:661811. doi: 10.3389/fimmu.2021.661811

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Copyright © 2021 Trachalaki, Tsitoura, Mastrodimou, Invernizzi, Vasarmidi, Bibaki, Tzanakis, Molyneaux, Maher and Antoniou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial Oxidation status and the inflammasome. (A) MtROS Mean Florescence Intensity Index (MFI) as assessed by flowcytometry in healthy and ILD patients. ILD Patients were categorised according to MtROS MFI using the cut-off value of 1.5(generated by ROC curve). Comparisons on inflammasome activation were made in MtROS high and low groups (B) NLRP3 activation without LPS priming, (C) NLRP3 activation with LPS priming, (D) AIM2 activation (LPS priming followed by dsDNA transfection). Data presented as median with interquartile range, *p<0.05, **p<0.005, Mann-Whitney test.