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Bacterial burden and the inflammasome. (A) Bacterial burden in bronchoalveolar lavage (BAL) of healthy and ILD subjects. Bacterial burden calculated by qPCR and expressed as log10 (16S rRNA gene copies/ml of BAL). Mann-Whitney test. Data are presented as median and interquartile range, *p<0.05. Illustrating correlation between bacterial burden and (B) IL-1β release from AMs (Spearman correlation) and (C) AIM2 and (D) IL-18 log relative mRNA expression (Pearson Correlation).
