Figure 10.

The structure of the apo RdRp complex. (A) The schematic diagram for the components of the RdRp complex, which contains nsp7, nsp8, and nsp12. The polymerase motif (A-G) and β-hairpin are highlighted because it is unique to the SARS-CoV-2. (B, C) Two views structure of the apo nsp12-nsp7-nsp8 complex. nsp12 consists of an N-terminal β-hairpin (residues 31–50) and an extended nidovirus RdRp-associated nucleotidyl-transferase domain (NiRAN, residues 115–250). An interface domain (residues 251–365) is following the NiRAN domain. The nsp12 RdRp domain shows the canonical cupped right-handed configuration with the finger subdomain. NiRAN, Interface, Fingers, Thumb, Palm, nsp7, nsp8 are shown in orange, gray, hot pink, green, blue, cyan, and violet, respectively. (D) The conserved zinc-binding motifs in the apo structure rendered in ribbon are highlighted. The residues are shown as green sticks, and zinc is shown as red spheres. All structures are drawn by Pymol.