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D-optimal mixture design generated contour plots demonstrating the effect of Labrasol, Tween 80 and Labrafac lipophile WL 1349 on the Particle size of the prepared AZD-loaded PEHVs (a) in absence of Transcutol and (b) in presence of 5 mg Transcutol. Moving from red (light) to blue (dark) color indicates increasing particle size.
