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D-optimal mixture design generated contour plots demonstrating the effect of Labrasol, Transcutol and Labrafac lipophile WL 1349 on the entrapment efficiencies of the prepared AZD-loaded PEHVs (a) in absence of Tween 80, (b) in presence of 5 mg Tween 80 and (c) in presence of 10 mg Tween 80. Moving from red (light) to blue (dark) color indicates increasing entrapment efficiencies.
