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D-optimal mixture design generated contour plots showing the effect of Labrasol, labrafac lipophile Wl 1349 and Tween 80 on the percentage drug released after 24 h of AZD from the prepared penetration enhancing hybridized vesicles (a) in absence of Transcutol and (b) in the presence of 15 mg Transcutol. Moving from blue (dark) to lighter colors indicate higher percentages released.
