Table 2. Comparison between the in vivo efficacy of acetazolamide PEHVs compared to 1% acetazolamide solution and conventional liposomes.

Acetazolamide formulation	Maximum value of lowering IOP (mmHg) ± S.D.	Duration of action (lowering IOP) (h)	Area under the curve (AUC) (mmHg.h) ± S.D.
Acetazolamide 1% solution	−3.75 ± 0.07	4	11.78 ± 1.54
PEHVs-F7	−7.6 ± 1.28	>24 hrs	99.08 ± 20.1
PEHVs-F15	−7.3 ± 0.65	12	44.22 ± 10.38
Conventional liposomes-F18	−5.7 ± 0.77	12	51.65 ± 10.77