Table 4.

Univariate and Multivariate Cox Regression Analysis for NF2-Related Deaths—Unadjusted Estimates

		Univariate			Multivariate
		Hazard Ratio	95% Confidence Interval		Hazard Ratio	95% Confidence Interval
Gender	Male	Ref			Ref
	Female	1.06	0.55	2.05	1.25	0.63	2.47
Age at diagnosis		0.98	0.95	1.001
Age at symptoms	<16	Ref			Ref
	16-25	0.56	0.25	1.22	0.51	0.22	1.20
	26-39	0.23	0.08	0.68	0.34	0.10	1.16
	>40	0.27	0.06	1.18	0.44	0.09	2.18
	Asymptomatic	0.09	0.01	0.64	0.16	0.02	1.32
Inherit type	Constitutional	Ref			Ref
	Inherited	0.36	0.17	0.76	0.61	0.24	1.53
	Mosaic	0.47	0.18	1.26	0.83	0.21	3.24
	Unknown	0.12	0.02	0.89	0.16	0.02	1.47
Genetic severity	Severe	Ref			Ref
	Mild	0.25	0.12	0.56	0.66	0.23	1.89
	Moderate	0.23	0.10	0.52	1.42	0.46	4.40
Bilateral VS	No	Ref
	Yes	3.28	0.45	23.96
Meningioma	No	Ref			Ref
	Yes	2.39	1.12	5.09	0.96	0.44	2.58
Ependymoma	No	Ref			Ref
	Yes	2.76	1.44	5.31	1.59	0.74	3.44
Bevacizumab	No	Ref
	Yes	0.61	0.21	1.72
Spinal operation	No	Ref			Ref
	Yes	2.29	1.12	4.67	1.59	0.72	3.52
Meningioma operation	No	Ref
	Yes	1.40	0.67	2.91

Abbreviation: Ref, reference, worst category used.