Fig. 3.

Typical morphologic and physiologic MRI appearance of PCNSL. PCNSL classically appears as a diffuse often periventricular enhancing mass (top left). T2-weighted imaging is often heterogenous but frequently demonstrates a mass like hypointense component (top middle) within enhancing regions. Increasing tumor cellularity is associated with decreasing T2 and ADC hypointensity (top right). Likewise, the degree of angiogenesis is reflected by DSC and DCE perfusion MRI sequences. CBV (bottom left) and K^trans (bottom right) are quite heterogenous in PCNSL and may be reflective of tumor aggressiveness.