Table 2.

Univariable Cox Regression of Event-Free Survival

Parameter	Group Comparison	N	Events	Hazard Ratio	Lower 95% CL	Upper 95% CL	P
Dissemination (n = 128)	No dissemination	112	61				<.001
	Disseminated disease	16	15	3.48	1.95	6.24
Age at diagnosis (n = 128)	≥11 y	39	16				.008
	5-10 y	47	29	1.75	0.95	3.22
	0-4 y	42	31	2.53	1.38	4.64
Extent of resection (n = 121)a	Total resection	24	8				.001
	Subtotal resection	14	8	2.09	0.79	5.58
	Partial resection	63	38	2.73	1.27	5.87
	Biopsy	20	17	5.50	2.36	12.83
Histology (n = 124)	PA	94	57				.300
	DG2	12	5	0.59	0.24	1.48
	Other	18	13	1.29	0.71	2.36
Sex (n = 128)	Female	50	31				.342
	Male	78	45	0.80	0.51	1.27
Neurofibromatosis (n = 126)	Negative	119	70				.798
	NF-1	7	4	1.14	0.42	3.14
Tumor volume (n = 80)	<7 mL	42	20				.126
	≥7 mL	38	24	1.59	0.88	2.90
Localization (n = 125)	Cervical	25	13				.194
	Cervicothoracic	42	30	1.66	0.86	3.18
	Thoracic	50	29	1.16	0.60	2.24
	Thoraco-lumbar	8	3	0.64	0.18	2.25
MMCS at diagnosisb (n = 119)	I-II	45	25				.249
	III	34	19	1.06	0.59	1.93
	IV-V	40	27	1.55	0.90	2.68
MIB-1 index (n = 109)	<1%	18	10				.411
	1-5%	71	40	1.06	0.53	2.13
	≥5%	20	14	1.60	0.71	3.61
p53 accumulation (n = 91)	Negative	74	46				.163
	Positive	17	8	0.60	0.28	1.28
BRAFV600E status (n = 66)	No mutation	64	43				.633
	BRAFV600E mutation	2	1	0.64	0.09	4.66
Fusion status (n = 35)	No fusion	18	12				.566
	KIAA1549-BRAF fusion	14	10	1.32	0.55	3.14
	FGFR1-TACC1 fusion	3	2	0.61	0.14	2.78

Bold values indicate statistically significant findings.

Abbreviation: MMCS, modified McCormick scale.^12,28

^aExclusion of 4 patients without resection and 3 patients with event before first resection.

^bExclusion of 9 patients presenting with symptoms of increased intracranial pressure without motor/sensory deficits.