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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Nat Cancer. 2021 Jan 25;2(2):233–244. doi: 10.1038/s43018-020-00169-2

Fig. 1 |. Study design.

Fig. 1 |

Three distinct translation challenges are considered. Each challenge involves a pretraining phase (top) based on cell-line response data across tissues, followed by a few-shot learning phase (bottom) in which data in the new context are presented for additional learning, one sample at a time. Challenge 1: transfer of CRISPR (challenge 1a) or drug (challenge 1b) response model for prediction in the context of a new tissue. Challenge 2: transfer of model to PDTCs in vitro. Challenge 3: transfer of model to PDXs in vivo.