Appendix 2—table 5. Biliary glucuronide secretion rate and liver recycling efficiency of 16 different glucuronides.

Infused compound (10 μM)	Secretion rate (nmol/hr)*	LRE%†
Ezetimibe-4'-G	19.31 ± 1.85	96.5 ± 9.2
Wogonin-7-G(wogonoside)	16.3 ± 4.28	81.5 ± 21.4
Raloxifene-4'-G	11.48 ± 2.32	57.4 ± 11.6
Apigenin-7-G	10.64 ± 4.49	53.2 ± 22.4
Raloxifene-6-G	10.53 ± 1.51	52.6 ± 7.5
Chrysin-7-G	9.91 ± 1.92 ‡	49.6 ± 9.6 ‡
Genestein-7-G	9.45 ± 3.21 ‡	47.3 ± 16.0 ‡
Icaritin-7-G	7.46 ± 0.72	37.3 ± 3.6
Icaritin-3-G	5.35 ± 1.12	26.8 ± 5.6
Scuttelarin	4.34 ± 1.18	21.7 ± 5.9
Biochanin A-G	3.48 ± 0.75 ‡	17.5 ± 3.7 ‡
Luteolin-3’-G	1.33 ± 0.34	6.7 ± 1.7
Baicalin	0.69 ± 0.30	3.4 ± 1.5
Luteolin-7-glycoside	0.67 ± 0.56	3.4 ± 2.8
Quercetin-3-G	0.43 ± 0.57	2.2 ± 2.8
Ace-G	0.10 ± 0.06	0.5 ± 0.3

*The glucuronide secretion rate at the steady state was calculated by the linear regression of accumulated amount secreted in bile vs. time.

† LRE (liver recycling efficiency) % = Excretion rate at steady state/infusion rate.

‡ Data from previous published study (Zeng et al., 2016).