Appendix 2—table 7. Kinetic parameters of uptake (Km and Vmax) of selected glucuronides wogonoside, luteolin-3’-glucuronide (Lut-3’-glu) and apigenin-7-glucuronide (Api-7-glu) in OATP1B1/1B3/2B1 over-expressed cells.
| Compound | 1B1 | 1B3 | 2B1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Km(μM) | Vmax (pmol/min) |
Km(μM) | Vmax (pmol/min) |
Km(μM) | Vmax (pmol/min) |
||||||
| Won-7-G | 27.68 | 53.37 | >50 | 11.72 | >50 | 55.26 | |||||
| Lut-3’-G | 4.46 | 22.79 | >50 | 9.62 | 0.89 | 4.07 | |||||
| Api-7-G | >50 | >200 | >50 | >200 | 9.72 | 5.09 | |||||
| Eze-4'-G | >50 | 11.45 | 17.64 | 1.67 | 8.55 | 1.61 | |||||