Table 2.

Sex-specific coefficients and subdistribution hazard ratios for cardiovascular disease events of SCORE2-OP

	Men		Women
	Coefficients (95% CI)	Subdistribution hazard ratios	Coefficients (95% CI)	Subdistribution hazard ratios
Age (per year)	0.063 (0.055 to 0.071)	1.07	0.079 (0.070 to 0.087)	1.08
History of diabetes	0.425 (0.305 to 0.544)	1.50	0.601 (0.465 to 0.737)	1.80
History of diabetes × age (per year)	−0.017 (−0.040 to 0.005)		−0.011 (−0.032 to 0.011)
Current smoking	0.352 (0.279 to 0.426)	1.39	0.492 (0.398 to 0.587)	1.59
Current smoking × age (per year)	−0.025 (−0.040 to −0.009)		−0.026 (−0.043 to −0.008)
SBP (per 10 mmHg)	0.094   (0.079 to 0.109)	1.09	0.102 (0.085 to 0.119)	1.10
SBP (per 10 mmHg) × age (per year)	−0.005 (−0.008 to −0.002)		−0.004 (−0.007 to −0.002)
Total cholesterol (per 1 mmol/L)	0.085 (0.054 to 0.116)	1.10	0.060 (0.027 to 0.094)	1.06
Total cholesterol (per 1 mmol/L) × age (per year)	0.007 (0.002 to 0.013)		−0.001 (−0.056 to 0.004)
HDL cholesterol (per 1 mmol/L)	−0.356 (−0.445 to −0.268)	0.71	−0.304 (−0.403 to −0.205)	0.75
HDL cholesterol (per 1 mmol/L) × age (per year)	0.009 (−0.009 to 0.027)		0.015 (0.0002 to 0.031)

Sex-specific coefficients and subdistribution hazard ratios (SHRs) from Fine and Gray models predicted the risk of fatal and non-fatal CVD events as derived in the CONOR study. The SHRs are shown for age centred at 73 years, systolic blood pressure at 150 mmHg, total cholesterol at 6 mmol/L, and HDL cholesterol at 1.4 mmol/L. These SHRs are relevant for risk estimation only and have no aetiological interpretation.

CI, confidence interval; CVD, cardiovascular disease; HDL, high-density lipoprotein; SBP, systolic blood pressure.