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. 2021 Jun 23;48(2):155. doi: 10.3892/ijmm.2021.4988

Figure 5.

Figure 5

Effect of LRC on GIOP in an ACD mouse model. DEX (2 mg/kg) was applied for 8 weeks following the induction of ACD using 2,4-dinitrochlorobenzene on the skins of mice. LRC extract (50 and 100 mg/kg) or distilled water were orally administered to the mice. (A) After 8 weeks, the mouse femurs were analyzed by micro-CT. (B) The femurs were sectioned and stained with hematoxylin and eosin. The mouse bone parameters such as (C) BMD, (D) BV/TV, (E) Tb.Sp, (F) Tb.N, (G) BS/TV and (H) Tb.Th were analyzed by micro-CT. Data represent the means ± SEM of experiments. #P<0.05, ##P<0.01 vs. normal animals; *P<0.05, **P<0.01 vs. GC animals. LRC, Lycii radicis cortex; ACD, allergic contact dermatitis; GIOP, GC-induced osteoporosis; DEX, dexamethasone; CT, computed tomography; GC, glucocorticoid; bone mineral density, BMD; bone volume/total volume, BV/TV; trabecular separation, Tb.Sp; trabecular number, Tb.N; trabecular thickness, Tb.Th; bone surface density.