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. 2021 Jun 4;3(3):fcab127. doi: 10.1093/braincomms/fcab127

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mediation analysis. Mediation scheme after Preacher and Hayes³⁸ shown for the relation between HVP, TGM volume and MoCA Score. A) The total effect of the subject-level HVP on the MoCA score. B) The average direct effect is represented by cʹ. The average causal mediation effect is represented by a*b. Together, average direct effect and average causal mediation effect amount to the total effect (c = cʹ + ab).