Table 1.
Structural alignment values and data for endogenous hits.
| Representative PDB |
||||||||
|---|---|---|---|---|---|---|---|---|
| MERS-CoV | SARS-CoV | SARS-CoV-2 | Mimic UniProt Name | Alignment Length | Alignment Sequence Identity (%) | TM-score | RMSD | Tools |
| 1mox | Transforming growth factor alpha | 25 | 4 | 0.25 | 3.53 | R | ||
| 1dx5 | 1zaq | 1dqb | Thrombomodulin | 21;20;25 | 4.8;5;4 | 0.31074;0.20501;0.2719 | 2.76;3.02;3.08 | R,P and H (SARS-CoV-2) |
| 5ky0 | 1toz | Neurogenic locus notch homolog protein 1 | 18;23 | 5.6;4.3 | 0.29958;0.26322 | 2.04;2.67 | R,P | |
| 5mwb | Neurogenic locus notch homolog protein 2 | 19 | 0 | 0.23683 | 2.81 | R | ||
| 1xka | 2vwl | 1fjs | Coagulation factor X | 23;21 | 17.4;0 | 0.29888;0.24978 | 2.67;2.88 | R,P |
| 3th4 | 5ky2 | 1bf9 | Coagulation factor VII | 25;22 | 8;4.5 | 0.27601;0.25062 | 3.00;2.97 | R,P |
| 5f85 | 1edm | Coagulation factor IX | 17;20 | 5.9;5 | 0.33731;0.25615 | 1.27;2.91 | R,P | |
| 3bt1 | 2fd6 | Urokinase-type plasminogen activator | 23 | 8.7 | 0.25522 | 3.13 | R | |
| 5wb7 | Epiregulin | 19;25 | 5.3;4 | 0.30636;0.23605 | 2.39;3.52 | R | ||
| 5wb8 | Epigen | 22 | 13.6 | 0.34781 | 2.67 | R | ||
| 1emn | 1emn | Fibrillin | 26;25;27 | 3.8;8;11.1 | 0.24425;0.26079 | 2.67;3.40;3.59 | R | |
| 4hsv | 1rhp | 1nap | Platelet factor 4 (Platelet basic protein) | 26;23;25 | 3.8;4.3;8 | 0.33673;0.19566;0.28516 | 2.67;3.77;2.97 | R, H and P (SARS-CoV-2) |
| 2r3z | 1o7z | Small inducible cytokine B10 | 27;28 | 0;7.1 | 0.28217;0.30758 | 3.38;2.9 | R | |
| 3oj2 | 3cu1 | Fibroblast growth factor 1 | 37;21 | 5.4;14.3 | 0.29384;0.27446 | 3.54;2.74 | H,P | |
| 4c2b | von Willebrand factor | 31 | 3.2 | 0.27715 | 3.53 | H | ||
| 1b3e | 1b3e | Serotransferrin | 54;50 | 7.4;10 | 0.42052;0.41965 | 3.86;3.83 | T | |
| 4l0p | 4m4r | Ephrin-A5 | 39;37 | 10.3;2.7 | 0.27482;0.31208 | 4.36;3.68 | H | |
| 2wo2 | Ephrin-B2 | 34 | 8.8 | 0.3341 | 3.08 | H | ||
| 1b53 | 1b50 | C-C motif chemokine 3 | 26;22 | 0;0 | 0.24893;0.21513 | 3.13;2.97 | R | |
| 2h62 | Bone morphogenetic protein 2 | 32 | 3.1 | 0.28716 | 3.69 | H | ||
| 4xfu | 4r6u | Interleukin-18 | 31;46 | 0;2.2 | 0.33910;0.34459 | 2.88;4.37 | R | |
| 1qnk | C-X-C motif chemokine 2 | 27 | 7.4 | 0.2786 | 3.53 | P | ||
| 1je4 | C-C motif chemokine 4 | 24 | 8.3 | 0.32333 | 3.12 | P | ||
| 3qb4 | Growth/differentiation factor 5 | 39 | 17.9 | 0.35895 | 3.78 | H | ||
| 5mw5 | Jagged-2 | 38 | 15.8 | 0.54617 | 2.56 | T | ||
| 4xbm | Delta-like protein 1 | 37 | 5.4 | 0.51041 | 2.32 | T | ||
| 5mvx | Delta-like protein 4 | 38 | 5.3 | 0.50604 | 2.47 | T | ||
| 5fuc | Interleukin-6 receptor subunit alpha | 36 | 0 | 0.34661 | 2.87 | R | ||
| 1pvh | Interleukin-6 receptor beta chain | 34 | 5.9 | 0.32838 | 3.51 | R | ||
| 4nqc | TCR beta chain | 28 | 10.7 | 0.40641 | 2.42 | H | ||
| 5t5w | Interferon lambda receptor 1 | 27 | 7.4 | 0.37707 | 2.65 | H | ||
| 2hey | Tumor necrosis factor receptor superfamily member 4 | 32 | 6.2 | 0.31459 | 3.33 | R | ||
| 1ncf | Tumor necrosis factor receptor superfamily member 1A | 24 | 4.2 | 0.29911 | 2.94 | R | ||
| 2aw2 | Tumor necrosis factor receptor superfamily member 14 | 25 | 12 | 0.23837 | 3.42 | R | ||
| 1oqe | Tumor necrosis factor receptor superfamily member 13C | 23 | 4.3 | 0.25858 | 3.29 | R,P | ||
| 3v56 | Tumor necrosis factor ligand superfamily member 13B | 40 | 12.5 | 0.39446 | 3.31 | H,R | ||
| 4en0 | Tumor necrosis factor ligand superfamily member 14 | 37 | 16.2 | 0.44547 | 2.86 | H,R | ||
| 1hfh | 5o32 | 1hfi | Complement factor H | 33;35;28 | 9.1;2.9;3.6 | 0.3487;0.31744;0.27510 | 3.39;3.82;3.57 | R,P (no SARS-CoV),H (SARS-CoV) |
| 3oed | Complement receptor type 2 (CR2) | 31 | 6.5 | 0.3175 | 3.23 | H,R,P | ||
| 6f1c | Complement C1s | 23 | 8.7 | 0.38981 | 2.02 | H | ||
| 1x5y | Fibronectin type-III domain of mouse myosin-binding protein C | 28 | 14.3 | 0.42255 | 2.45 | R | ||
| 2cum | Fibronectin type III domain of human Tenascin-X | 29 | 3.4 | 0.40251 | 2.8 | R | ||
| 3f5n | Neuroserpin | 41 | 12.2 | 0.36905 | 3.58 | H | ||
| 3h6s | Clitocypin-5 cysteine proteinase | 34 | 2.9 | 0.32861 | 3.45 | H | ||
| 2yhf | C-type lectin domain family 5 member A | 30 | 3.3 | 0.30137 | 3.42 | H | ||
| 3bn3 | Intercellular adhesion molecule 5 | 39 | 3.34 | 0.36204 | 3.34 | H | ||
| 3sq9 | 3u8m | Acetylcholine-binding protein | 38;38 | 13.2;10.5 | 0.35462;0.38651 | 3.69;3.14 | R | |