Table 2.

Sex hormone-regulated lncRNA and its role in cancer

Sex hormone receptor	lncRNA	Cancer type	Relation with sex hormone receptor	Role in cancer	Reference
ER	HOTAIR	Breast cancer	Inhibited by ER	Induce proliferation and tamoxifen resistance	[100]
	ERINA		Inhanced transactivation by ER	Induce proliferation and growth	[101]
	TROJAN, MIAT		High in ER-positive breast cancer	Induce proliferation	[102,105]
	TMPO-AS1		Stabilize ESR1 mRNA	Induce proliferation	[103]
	TCL6		Low in ER-positive breast cancer	High probability in high expression patients	[104]
	H19	Thyroid cancer	Promoted transcription by ERb	High probability in low expression patients	[106]
	MALAT1	Lung cancer	Increased expression by ERb	Induce vasculogenic mimicry formation and invasion	[107]
	HOTAIR	Renal cancer	Inhanced by ER	Induce proliferation and invasion	[108]
	LINC00263	Lung cancer, Colorectal cancer, Renal cancer	Inhibited by ER	High expression in cancer tissue	[109]
AR	ARLNC1	Prostate cancer	Induced by AR, stabilize AR transcription	Induce proliferation and growth	[113]
	LINC00844		Regulate the transcriptional regulation of androgen-related genes	Induce proliferation and progression	[114]
	PRCAT38		Increased through AR transactivation	Induce proliferation	[115]
	LINC00304		Inhibit AR	Induce proliferation and cell cycle progression	[116]
	SARCC	Renal cancer	Inhibit activity of AR	Suppress tumor	[117]
	HOTAIR		Promote activity of AR	Induce tumor angiogenesis	[118]
	SLNCR	Melanoma	Combined with AR	Induce proliferation	[119]
	PART1	Lung cancer, Colon cancer	Induced by androgen	Promote progression	[120,121]

LncRNA, Long non-coding RNA; ER, estrogen receptor; ESR1, estrogen receptor 1 gene; AR, androgen receptor.