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. 2021 Jun 17;11:679712. doi: 10.3389/fonc.2021.679712

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Copyright © 2021 Liu, Yang, Zhang and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of LPCAT1 suppressed PCa cell proliferation and migration (A) LPCAT1, DNA-PKcs, RAD51 were highly expressed in PCa cell lines (PC3, DU145, LnCaP) when compared to RWPE-1 (normal prostate epithelial cell). (B) Inhibition of LPCAT1 downregulated DNA-PKcs and RAD51 expressions in PC-3 cells. (C, D) Cloning formation and migration assays showed that downregulation of LPCAT1 suppressed PC-3 cell proliferation and migration. Data are presented as mean ± SD. ^### P < .001.