Table 1.
Overview of mutations of target genes
| ACC n = 37 |
ACA n = 32 |
Normal gland n = 25 |
|
|---|---|---|---|
| Sum of gene mutations | 132 | 30 | 16 |
| MEN1 | 20 | 14 | 10 |
| ZNRF3 | 20 | 2 | 1 |
| ARMC5 | 19 | 2 | 1 |
| TP53 | 19 | 2 | 2 |
| CTNNB1 | 13 | 7 | 0 |
| APC | 12 | 1 | 2 |
| RB1 | 11 | 0 | 0 |
| PRKAR1A | 9 | 0 | 0 |
| RPL22 | 9 | 2 | 0 |
| Number of mutated genes, Median (range) | 4.0 (1.5–6.0) |
1.0 (0–1.0) P < 0.001 |
1.0 (0–1.0) P < 0.001 |
| Sum of mutation sites | 227 | 35 | 18 |
| Nonsynonymous SNV | 169 | 21 | 13 |
| Frameshift deletion | 19 | 10 | 3 |
| Frameshift insertion | 0 | 0 | 0 |
| Stopgain | 19 | 0 | 0 |
| Stoploss | 1 | 0 | 0 |
| Splicing | 19 | 4 | 2 |
| Number of mutation sites, Medan (range) | 4.0 (2.0–10.0) |
1.0 (0–2.0) P < 0.001 |
1.0 (0–1.0) P < 0.001 |