Fig. 3.

Visual predictive checks of the final isoniazid population pharmacokinetic model for a slow metabolizers and b fast metabolizers. The visual predictive checks are based on 1000 simulations and prediction corrected. The PsN mixture option was used and the plots are based on the individual probability for belonging to a subpopulation [36]. The solid lines represent the mean of the observed concentrations and the dashed lines represent the 2.5th and 97.5th percentiles. The shaded areas represent the 95% confidence interval of the 2.5th, 50th, and 97.5th percentiles of the simulated concentrations