Table 3.
The association between nuclear DDIT4 expression and clinicopathological features of colorectal cancer (CRC) samples (Intensity of staining and H-score).
| Patients and tumor characteristics | Total samples N (%) | Intensity of staining N (%) | P value | H-score (cut off = 210) N (%) | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| 0 (Negative) | 1+ (Weak) | 2+ (Moderate) | 3+ (Strong) | Low (≤ 210) | High (> 210) | ||||
| Mean age, years (Range) | 59 (25–88) | 0.991 | 0.769 | ||||||
| ≤ Mean age | 98 (49.5) | 0 (0.0) | 3 (50.0) | 43 (50.0) | 52 (49.1) | 45 (48.4) | 53 (50.5) | ||
| > Mean age | 100 (50.5) | 0 (0.0) | 3 (50.0) | 43 (50.0) | 54 (50.9) | 48 (51.6) | 52 (49.5) | ||
| Gender | 0.760 | 0.966 | |||||||
| Male | 104 (52.5) | 0 (0.0) | 4 (66.7) | 44 (51.2) | 56 (52.8) | 49 (52.7) | 55 (52.4) | ||
| Female | 94 (47.5) | 0 (0.0) | 2 (33.3) | 42 (48.8) | 50 (47.2) | 44 (47.3) | 50 (47.6) | ||
| (Male/Female) | 1.1 | - | 2 | 1.0 | 1.1 | 1.1 | 1.1 | ||
| Mean tumor size (cm) | 5 | 0.159 | 0.985 | ||||||
| ≤ Mean | 134 (67.7) | 0 (0.0) | 2 (33.3) | 61 (70.9) | 71 (67.0) | 63 (67.7) | 71 (67.6) | ||
| > Mean | 64 (32.3) | 0 (0.0) | 4 (66.7) | 25 (29.1) | 35 (33.0) | 30 (32.3) | 34 (32.4) | ||
| Tumor differentiation | 0.031 | 0.009 | |||||||
| Well | 90 (45.5) | 0 (0.0) | 2 (33.3) | 50 (58.1) | 38 (35.8) | 53 (57.0) | 37 (35.2) | ||
| Moderately | 95 (48.0) | 0 (0.0) | 4 (66.7) | 31 (36.0) | 60 (56.6) | 35 (37.6) | 60 (57.1) | ||
| Poorly | 13 (6.6) | 0 (0.0) | 0 (0.0) | 5 (5.8) | 8 (7.5) | 5 (5.4) | 8 (7.6) | ||
| TNM stages | 0.013 | 0.009 | |||||||
| I | 31 (15.7) | 0 (0.0) | 0 (0.0) | 10 (11.6) | 21 (19.8) | 11 (11.8) | 20 (19.0) | ||
| II | 81 (40.9) | 0 (0.0) | 3 (50.0) | 46 (53.5) | 32 (30.2) | 48 (51.6) | 33 (31.4) | ||
| III | 79 (39.9) | 0 (0.0) | 3 (50.0) | 25 (29.1) | 51 (48.1) | 29 (31.2) | 50 (47.6) | ||
| IV | 7 (3.5) | 0 (0.0) | 0 (0.0) | 5 (5.8) | 2 (1.9) | 5 (5.4) | 2 (1.9) | ||
| Vascular invasion (VI) | 0.874 | 0.848 | |||||||
| Present | 33 (16.7) | 0 (0.0) | 1(16.7) | 13 (15.1) | 19 (17.9) | 15 (16.1) | 18 (17.1) | ||
| Absent | 165 (83.3) | 0 (0.0) | 5 (83.3) | 73 (84.9) | 87 (82.1) | 78 (83.9) | 87 (82.9) | ||
| Lymph node invasion (LNI) | 0.343 | 0.199 | |||||||
| Involved | 84 (42.4) | 0 (0.0) | 2 (33.3) | 32 (37.2) | 50 (47.2) | 35 (37.6) | 49 (46.7) | ||
| None | 114 (57.6) | 0 (0.0) | 4 (66.7) | 54 (62.8) | 56 (52.8) | 58 (62.4) | 56 (53.3) | ||
| Perineural invasion (PI) | 0.314 | 0.629 | |||||||
| Involved | 48 (24.2) | 0 (0.0) | 3 (50.0) | 21 (24.4) | 24 (22.6) | 24 (25.8) | 24 (22.9) | ||
| None | 150 (75.8) | 0 (0.0) | 3 (50.0) | 65 (75.6) | 82 (77.4) | 69 (74.2) | 81 (77.1) | ||
| Distant metastasis | 0.500 | 0.989 | |||||||
| Present | 28 (14.1) | 0 (0.0) | 0 (0.0) | 11 (25.6) | 17 (26.2) | 12 (25.0) | 16 (25.0) | ||
| Absent | 84 (42.4) | 0 (0.0) | 4 (100.0) | 32 (74.4) | 48 (73.8) | 36 (75.0) | 48 (75.0) | ||
| Tumor recurrence | 0.381 | 0.533 | |||||||
| Yes | 29 (14.6) | 0 (0.0) | 0 (0.0) | 10 (23.3) | 19 (29.2) | 11 (22.9) | 18 (28.1) | ||
| No | 83 (41.9) | 0 (0.0) | 4 (100.0) | 33 (76.7) | 46 (70.8) | 37 (77.1) | 46 (71.9) | ||
P value; Pearson’s χ2 test, and Values in bold are statistically significant.
H-score histological score.