Table 4.
The association between cytoplasmic DDIT4 expression and clinicopathological features of colorectal cancer (CRC) samples (Intensity of staining and H-score).
| Patients and tumor characteristics | Total samples N (%) | Intensity of staining N (%) | P value | H-score (cut off = 180) N(%) | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| 0 (Negative) | 1+ (Weak) | 2+ (Moderate) | 3+ (Strong) | Low (≤ 180) | High (> 180) | ||||
| Mean age, years (Range) | 59 (25–88) | 0.187 | 0.640 | ||||||
| ≤ Mean age | 98 (49.5) | 0 (0.0) | 8 (66.7) | 69 (51.5) | 21 (40.4) | 61 (50.8) | 37 (47.4) | ||
| > Mean age | 100 (50.5) | 0 (0.0) | 4 (33.3) | 65 (48.5) | 31 (59.6) | 59 (49.2) | 41 (52.6) | ||
| Gender | 0.557 | 0.377 | |||||||
| Male | 104 (52.5) | 0 (0.0) | 8 (66.7) | 68 (50.7) | 28 (53.8) | 60 (50.0) | 44 (56.4) | ||
| Female | 94 (47.5) | 0 (0.0) | 4 (33.3) | 66 (49.3) | 24 (46.2) | 60 (50.0) | 34 (43.6) | ||
| (Male/Female) | 1.1 | - | 2.0 | 1.0 | 1.1 | 1.0 | 1.2 | ||
| Mean tumor size (cm) | 5 | 0.679 | 0.578 | ||||||
| ≤ Mean | 134 (67.7) | 0 (0.0) | 9 (75.0) | 92 (68.7) | 33 (63.5) | 83 (69.2) | 51 (65.4) | ||
| > Mean | 64 (32.3) | 0 (0.0) | 3 (25.0) | 42 (31.3) | 19 (36.5) | 37 (30.8) | 27 (34.6) | ||
| Tumor differentiation | 0.554 | 0.987 | |||||||
| Well | 90 (45.5) | 0 (0.0) | 8 (66.7) | 60 (44.8) | 22 (42.3) | 54 (45.0) | 36 (46.2) | ||
| Moderately | 95 (48.0) | 0 (0.0) | 4 (33.3) | 64 (47.8) | 27 (51.9) | 58 (48.3) | 37 (47.4) | ||
| Poorly | 13 (6.6) | 0 (0.0) | 0 (0.0) | 10 (7.5) | 3 (5.8) | 8 (6.7) | 5 (6.4) | ||
| TNM stages | 0.0466 | 0.375 | |||||||
| I | 31 (15.7) | 0 (0.0) | 2 (16.7) | 21 (15.7) | 8 (15.4) | 15 (12.5) | 16 (20.5) | ||
| II | 81 (40.9) | 0 (0.0) | 5 (41.7) | 60 (44.8) | 16 (30.8) | 53 (44.2) | 28 (35.9) | ||
| III | 79 (39.9) | 0 (0.0) | 5 (41.7) | 47 (35.1) | 27 (51.9) | 47 (39.2) | 32 (41.0) | ||
| IV | 7 (3.5) | 0 (0.0) | 0 (0.0) | 6 (4.5) | 1 (1.9) | 5 (4.2) | 2 (2.6) | ||
| Vascular invasion (VI) | 0.207 | 0.696 | |||||||
| Present | 33 (16.7) | 0 (0.0) | 3 (25.0) | 18 (13.4) | 12 (23.1) | 21 (17.5) | 12 (15.4) | ||
| Absent | 165 (83.3) | 0 (0.0) | 9 (75.0) | 116 (86.6) | 40 (76.9) | 99 (82.5) | 66 (84.6) | ||
| Lymph node invasion (LNI) | 0.106 | 0.979 | |||||||
| Involved | 84 (42.4) | 0 (0.0) | 6 (50.0) | 50 (37.3) | 28 (53.8) | 51 (42.5) | 33 (42.3) | ||
| None | 114 (57.6) | 0 (0.0) | 6 (50.0) | 84 (62.7) | 24 (46.2) | 69 (57.5) | 45 (57.7) | ||
| Perineural invasion (PI) | 0.818 | 0.517 | |||||||
| Involved | 48 (24.2) | 0 (0.0) | 2 (16.7) | 33 (24.6) | 13 (25.0) | 31 (25.8) | 17 (21.8) | ||
| None | 150 (75.8) | 0 (0.0) | 10 (83.3) | 101 (75.4) | 39 (75.0) | 89 (74.2) | 61 (78.2) | ||
| Distant metastasis | 0.976 | 0.912 | |||||||
| Present | 28 (14.1) | 0 (0.0) | 2 (22.2) | 18 (25.0) | 8 (25.8) | 16 (24.6) | 12 (25.5) | ||
| Absent | 84 (42.4) | 0 (0.0) | 7 (77.8) | 54 (75.0) | 23 (74.2) | 49 (75.4) | 35 (74.5) | ||
| Tumor recurrence | 0.736 | 0.717 | |||||||
| Yes | 29 (14.6) | 0 (0.0) | 3 (33.3) | 17 (23.6) | 9 (29.0) | 16 (24.6) | 13 (27.7) | ||
| No | 83 (41.9) | 0 (0.0) | 6 (66.7) | 55 (76.4) | 22 (71.0) | 49 (75.4) | 34 (72.3) | ||
P value; Pearson’s χ2 test, and Values in bold are statistically significant.
H-score histological score.