Table 5.
The association between membranous DDIT4 expression and clinicopathological features of colorectal cancer (CRC) samples (Intensity of staining and H-score).
| Patients and tumor characteristics | Total samples N (%) | Intensity of staining N (%) | P value | H-score (cut off = 200) N(%) | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| 0 (Negative) | 1+ (Weak) | 2+ (Moderate) | 3+ (Strong) | Low (≤ 200) | High (> 200) | ||||
| Mean age, years (Range) | 59 (25–88) | 0.328 | 0.143 | ||||||
| ≤ Mean age | 98 (49.5) | 0 (0.0) | 4 (66.7) | 53 (52.5) | 41 (46.1) | 62 (53.9) | 36 (43.4) | ||
| > Mean age | 100 (50.5) | 2 (100.0) | 2 (33.3) | 48 (47.5) | 48 (53.9) | 53 (46.1) | 47 (56.6) | ||
| Gender | 0.781 | 0.686 | |||||||
| Male | 104 (52.5) | 1 (50.0) | 4 (66.7) | 50 (49.5) | 49 (55.1) | 59 (51.3) | 45 (54.2) | ||
| Female | 94 (47.5) | 1 (50.0) | 2 (33.3) | 51 (50.5) | 40 (44.9) | 56 (48.7) | 38 (45.8) | ||
| (Male/Female) | 1.1 | 1.0 | 2.0 | 0.9 | 1.2 | 1.0 | 1.1 | ||
| Mean tumor size (cm) | 5 | 0.674 | 0.958 | ||||||
| ≤ Mean | 134 (67.7) | 1 (50.0) | 3 (50.0) | 71 (70.3) | 59 (66.3) | 78 (67.8) | 56 (67.5) | ||
| > Mean | 64 (32.3) | 1 (50.0) | 3 (50.0) | 30 (29.7) | 30 (33.7) | 37 (32.2) | 27 (32.5) | ||
| Tumor differentiation | 0.198 | 0.817 | |||||||
| Well | 90 (45.5) | 1 (50.0) | 4 (66.7) | 47 (46.5) | 38 (42.7) | 54 (47.0) | 36 (43.4) | ||
| Moderately | 95 (48.0) | 0 (0.0) | 2 (33.3) | 47 (46.5) | 46 (51.7) | 53 (46.1) | 42 (50.6) | ||
| Poorly | 13 (6.6) | 1 (50.0) | 0 (0.0) | 7 (6.9) | 5 (5.6) | 8 (7.0) | 5 (6.0) | ||
| TNM stages | 0.927 | 0.989 | |||||||
| I | 31 (15.7) | 0 (0.0) | 1 (16.7) | 17 (16.8) | 13(14.6) | 18 (15.7) | 13 (15.7) | ||
| II | 81 (40.9) | 0 (0.0) | 3 (50.0) | 40 (39.6) | 38(42.7) | 46 (40.0) | 35 (42.2) | ||
| III | 79 (39.9) | 2 (100.0) | 2 (33.3) | 40 (39.6) | 35(39.3) | 47 (40.9) | 32 (38.6) | ||
| IV | 7 (3.5) | 0 (0.0) | 0 (0.0) | 4 (4.0) | 3(3.4) | 4 (3.5) | 3 (3.6) | ||
| Vascular invasion (VI) | 0.634 | 0.941 | |||||||
| Present | 33 (16.7) | 0 (0.0) | 0 (0.0) | 17 (16.8) | 16 (18.0) | 19 (16.5) | 14 (16.9) | ||
| Absent | 165 (83.3) | 2 (100.0) | 6 (100.0) | 84 (83.2) | 73 (82.0) | 96 (83.5) | 69 (83.1) | ||
| Lymph node invasion (LNI) | 0.400 | 0.724 | |||||||
| Involved | 84 (42.4) | 2 (0.0) | 2 (33.3) | 43 (42.6) | 37 (41.6) | 50 (43.5) | 34 (41.0) | ||
| None | 114 (57.6) | 0 (0.0) | 4 (66.7) | 58 (57.4) | 52 (58.4) | 65 (56.5) | 49 (59.0) | ||
| Perineural invasion (PI) | 0.647 | 0.294 | |||||||
| Involved | 48 (24.2) | 1 (50.0) | 1 (16.7) | 27 (26.7) | 19 (21.3) | 31 (27.0) | 17 (20.5) | ||
| None | 150 (75.8) | 1 (50.0) | 5 (83.3) | 74 (73.3) | 70 (78.7) | 84 (73.0) | 66 (79.5) | ||
| Distant metastasis | 0.878 | 0.912 | |||||||
| Present | 28 (14.1) | 0 (0.0) | 1 (25.0) | 14 (25.5) | 13 (25.5) | 16 (25.4) | 12 (24.5) | ||
| Absent | 84 (42.4) | 2 (100.0) | 3 (75.0) | 41 (74.5) | 38 (74.5) | 47 (74.6) | 37 (75.5) | ||
| Tumor recurrence | 0.759 | 0.568 | |||||||
| Yes | 29 (14.6) | 0 (0.0) | 1 (25.0) | 13 (23.6) | 15 (29.4) | 15 (23.8) | 14 (28.6) | ||
| No | 83 (41.9) | 2 (100.0) | 3 (75.0) | 42 (76.4) | 36 (70.6) | 48 (76.2) | 35 (71.4) | ||
P value; Pearson’s χ2 test, and Values in bold are statistically significant.
H-score histological score.