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. 2021 Jul 2;6:247. doi: 10.1038/s41392-021-00650-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Mechanisms of NLRC4 inflammasome assembly and activation. The bacterial ligands such as needle protein, rod, and flagellin bind to NAIP proteins. Ligand-bound NAIP then interacts with NLRC4 to form the inflammasome through oligomerization. NLRC4 recruits pro-caspase-1 to the inflammasome via CARD–CARD interaction. Inset: NLRC4 inflammasome components