Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inflammasome activation contributes to the development of diseases. The NLRP3 inflammasome is activated by DAMPs such as ATP, excess glucose, cholesterol, and high fat, leading to the activation of caspase-1 and production of active IL-1β and IL-18 in cardiomyocytes, endothelial cells, and smooth muscle cells. These risk factors are also involved in the development of depression and T2D. CM cardiomyocyte, EC endothelial cell, SMC smooth muscle cell, T2D type 2 diabetes
