Fig. 5. Enzalutamide downregulates Tmprss2 in mouse lung.
a Relative expression of Ar, Tmprss2 and Ace2 mRNA from lung tissue of mice treated with enzalutamide (ENZA, n = 9) or vehicle control (VC, n = 8) once daily for 3 days. Expression was normalised to housekeeping genes and made relative to VC. Mean ± 1 SE. Student’s t-test (one-tailed) *p = 0.0367. b Example of Tmprss2 IHC in mouse lung. Representative immunostaining of epithelial cells (*) and parenchyma/AT cells (#) in sections from n = 9 VC-treated mice, and n = 8 ENZA-treated mice. Bar = 50 μm c Log2 expression of Tmprss2, Ar and Ace2 in lung tissue from male mice physically castrated (N = 3) vs intact male mice (N = 3) (GSE31341)50. Mean ± 1 SE. Student’s t-test (one-tailed), **p = 0.0018, *p = 0.0081. Source data are provided as a Source Data file.