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PDE values of nicotinic acid and its esters and nicotinamide calculated by using carcinogenicity data
| Species | Rat, orala Life span |
|
|---|---|---|
| Male | Female | |
| NOAEL (mg/kg/day) | 100.5 [35] | 66.3 [35] |
| F1 | 5 | 5 |
| F2 | 10 | 10 |
| F3 | 1 | 1 |
| F4 | 1 | 1 |
| F5 | 1 | 1 |
| PDEb (mg/day) | 100.5 | 66.3 |
The selection of F factors which is suitable for NOAEL or LOAE data is based on explanation in materials and method section
aData belongs to nicotinamide
bBody weight is 50 kg
