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PDE value calculated by using reproductive and developmental toxicity data for nicotinic acid and its esters and nicotinamide
| Species | Rat, orala Development toxicity including whole organogenesis period |
|---|---|
| NOAEL (mg/kg/day) | 200 [31] |
| F1 | 5 |
| F2 | 10 |
| F3 | 1 |
| F4 | 1 |
| F5 | 1 |
| PDEb (mg/day) | 200 |
The selection of F factors which is suitable for NOAEL or LOAE data is based on explanation in materials and method section
aData belongs to nicotinic acid
bBody weight is 50 kg
