Table 2.
Results of the in vitro chromosome aberration test for Dioscorea Rhizome water extract in CHL/IU cells with or without metabolic activation (S9 mixture)
Concentration (μg/mL) | S9 mixture | Time (h) | Platycodi radix water extract | |
---|---|---|---|---|
% Numerical aberration | % Structural aberration (Exclusive to gap) | |||
0 | – | 6 | 0.0 | 0.0 |
1250 | – | 6 | 0.0 | 0.0 |
2500 | – | 6 | 0.0 | 0.0 |
5000 | – | 6 | 0.0 | 0.3 |
Positive controla | – | 6 | 0.0 | 9.7** |
0 | + | 6 | 0.0 | 0.7 |
1250 | + | 6 | 0.0 | 0.0 |
2500 | + | 6 | 0.0 | 0.3 |
5000 | + | 6 | 0.0 | 0.3 |
Positive controlb | + | 6 | 0.0 | 18.0** |
0 | – | 22 | 0.0 | 0.0 |
1250 | – | 22 | 0.0 | 0.3 |
2500 | – | 22 | 0.0 | 0.0 |
5000 | – | 22 | 0.0 | 0.3 |
Positive controla | – | 22 | 0.0 | 11.0** |
**P < 0.01 compared with the negative control group
a4-Nitroquinoline-1-oxide 0.4 μg/mL
bBenzo[a]pyrene 20 μg/mL