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. 2021 Jan 2;37(3):385–393. doi: 10.1007/s43188-020-00077-8

Table 2.

Results of the in vitro chromosome aberration test for Dioscorea Rhizome water extract in CHL/IU cells with or without metabolic activation (S9 mixture)

Concentration (μg/mL) S9 mixture Time (h) Platycodi radix water extract
% Numerical aberration % Structural aberration (Exclusive to gap)
0 6 0.0 0.0
1250 6 0.0 0.0
2500 6 0.0 0.0
5000 6 0.0 0.3
Positive controla 6 0.0 9.7**
0  +  6 0.0 0.7
1250  +  6 0.0 0.0
2500  +  6 0.0 0.3
5000  +  6 0.0 0.3
Positive controlb  +  6 0.0 18.0**
0 22 0.0 0.0
1250 22 0.0 0.3
2500 22 0.0 0.0
5000 22 0.0 0.3
Positive controla 22 0.0 11.0**

**P < 0.01 compared with the negative control group

a4-Nitroquinoline-1-oxide 0.4 μg/mL

bBenzo[a]pyrene 20 μg/mL