Table 4.
Results of the in vivo micronucleus test for Dioscorea Rhizome water extract in the bone marrow of ICR mice
| Substance | Dose (mg/kg) | No. of animals | MNPCE/4000 PCE (%) | PCE/(PCE + NCE) (%) |
|---|---|---|---|---|
| Vehicle | 0 | 6 | 0.83 ± 1.0a | 0.54 ± 0.0a |
| DRWE | 1250 | 6 | 0.67 ± 0.8 | 0.50 ± 0.0 |
| DRWE | 2500 | 6 | 1.00 ± 0.0 | 0.55 ± 0.0 |
| DRWE | 5000 | 5 | 1.40 ± 2.2 | 0.53 ± 0.0 |
| CPA | 70 | 6 | 66.33 ± 19.2** | 0.39 ± 0.0** |
DRWE Dioscorea Rhizome water extract, CPA cyclophosphamide monohydrate, MNPCE micronucleated polychromatic erythrocyte, NCE normochromatic erythrocyte, PCE polychromatic erythrocyte
**P < 0.01 compared with the negative control group
aValues are presented as the mean ± SD (%)