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. 2021 Jul 1;11:13705. doi: 10.1038/s41598-021-91662-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Temporal and spatial distribution of the four possible D614G and P323L combinations. Available high-quality sequences of SARS-CoV-2 (27,075) were analysed. (a) G614/L323 (double mutant) represented more than two-thirds, and D614/P323 (the original Wuhan sequence) about one-third of sequences; the single mutant variants G614/P323 and D614/L323 were very rare, (b) weekly number of variants over time; (c) cumulative number of variants over time. (d) Percentage of variants in different countries; only countries with at least 20 sequences are represented.