FIGURE 1.

TRAP1 is down-regulated in different areas of the AD-brain. (A) The selected brain regions for proteomic analysis comparing patients with AD to non-AD counterparts (Xu et al., 2019). On the left, the lateral view of the left side of the brain, which contains the motor cortex and the sensory cortex. On the right the sagittal cut, revealing the cingulate gyrus, hippocampus, enthorinal cortex and cerebellum. The cingulate gyrus, hippocampus and enthorinal cortex are selected to represent heavily affected areas of the brain, the motor cortex and sensory cortex are less affected, while the cerebellum seems to be spared. Figure made with BioRender. (B) Heat map with the relative expression of elements of the protein quality control in the AD-brain compared to non-AD counterparts in different areas of the brain. Numbers represent the relative expression of that protein in an AD-patient compared to a non-AD counterpart (Koopman and Rüdiger, 2020). Included are the Hsp90 family, co-chaperones of HSP90, small heat shock proteins and nucleotide exchange factors. Notable is that the whole HSP90 family is affected in AD, with TRAP1 showing the largest decline in all areas of the brain.