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. 2021 Jun 18;8:680819. doi: 10.3389/fcvm.2021.680819

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Copyright © 2021 Chen, Barajas-Martínez, Xia, Zhang, Chen, Yang, Jiang, Antzelevitch and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative electrocardiograms of two ERS probands with CACNA1C. (A) Patient 1 was a 20-year-old male patient, identified with a mutation, P817S, in CACNA1C. He suffered syncopal episodes twice while exercising. ECGs showed bradycardia (HR = 46 bpm) and an ERP with notching in the inferior leads, leading to a diagnosis of ERS type 2. (B) Patient 2, a 17-year-old young male patient, presented with spontaneous VF on the background of syncope. ECGs exhibited sinus bradycardia (HR = 50 bpm) and an ERP with notching/slur in a global pattern, thus diagnosed with ERS type 3.