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. 2021 Jun 17;14:661368. doi: 10.3389/fnmol.2021.661368

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Copyright © 2021 Cantrelle, Loyens, Trivelli, Reimann, Despres, Gandhi, Hackenberger, Landrieu and Smet-Nocca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aggregation of TauPHF1 series induced by heparin. (A,B) Kinetics of TauPHF1 aggregation probed by ThT fluorescence emission plotted as mean ± standard deviation. (C,D) TEM images showing the fibril morphology of TauPHF1 isoforms with 20,000× (upper panels) and 85,000× (lower panels) magnification. The scale bars of the upper panels correspond to 2 μm and for the lower panels to 500 nm. Isoforms that are non-phosphorylated by GSK3β (Tau, Tau-G, and Tau-P) and phosphorylated by GSK3β (Tau-P(GSK3), Tau-G/P(GSK3), and Tau-PP) are depicted in (C) and (D), respectively. (E) Elongation rate constants calculated from curves fitted with a one-phase association model. The color coding is the same for all panels as indicated in (C) and (D) for the different TauPHF1 isoforms.