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Cohort 2: Likelihood of ctDNA mutation between 40 and 60% allele frequency being germline in origin.
| Gene | No. of mutations | No. germline (%) |
|---|---|---|
| TP53 | 36 | 9 (25) |
| BRCA2 | 27 | 26 (96.3) |
| BRCA1 | 22 | 20 (90.9) |
| CDH1 | 15 | 13 (86.7) |
| NF1 | 13 | 11 (84.6) |
| ATM | 9 | 6 (66.7) |
| CDKN2A | 7 | 6 (85.7) |
| CHEK2 | 6 | 6 (100) |
| APC | 6 | 1 (16.7) |
| ALK | 3 | 3 (100) |
| KIT | 3 | 3 (100) |
| MET | 3 | 3 (100) |
| RET | 3 | 2 (66.7) |
| RB1 | 3 | 0 (0) |
| PALB2 | 1 | 1 (100) |
| CDK4 | 1 | 1 (100) |
| PDGFRA | 1 | 0 (0) |
| PTEN | 1 | 0 (0) |
| Total | 160 | 69.4 (111) |
