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. 2021 Jan 28;31(7):773–790. doi: 10.1038/s41422-020-00464-8

Fig. 3. AT1a receptor mediates AAA formation in COMP–/– mice.

Fig. 3

a AngII concentrations in aortic explants from 5-month-old WT and COMP–/– mice. n = 11 animals per group; NS, no significance by Mann-Whitney test. b Western blot analysis of AT1 expression in the aortas of WT, COMP–/– and AT1a–/– mice. n = 3 mice per group. NS, no significance by One-way ANOVA followed by the Bonferroni test. c Representative images of the aortic morphology in COMP–/– or COMP–/–AT1a–/– mice infused with AngII (1000 ng/kg/min) for 28 days. d Incidence of AngII-induced AAA (COMP–/–: 6/7; COMP–/–AT1a–/–: 0/8). *P < 0.05 by χ2 test. e The maximal abdominal aortic diameters. COMP–/–, n = 7; COMP–/–AT1a–/–, n = 8. *P < 0.05 by Mann-Whitney test. f Quantification of elastin degradation. COMP–/–, n = 7; COMP–/–AT1a–/–, n = 6. *P < 0.05 by Mann-Whitney test.