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. 2021 Jul 1;12:4074. doi: 10.1038/s41467-021-24367-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Domain structures of human c-MET and HGF. The proteolytic cleavage site of c-MET is located between Arg307 and Ser308. The proteolytic cleavage site of HGF is located between Arg494 and Val495. C-MET927-LZ and full-length HGF were used for structural determination in this study. The dash boxes indicate the domains that were unsolved in cryo-EM maps. b 3D reconstruction of the 2:2 c-MET/HGF holo-complex and the corresponding ribbon representation of this complex fitted into the cryo-EM map at 4.8 Å resolution, shown in two orthogonal views. c The ribbon representation of c-MET/HGF holo-complex shown in two orthogonal views.