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. 2021 Jul 1;12:4074. doi: 10.1038/s41467-021-24367-3

Fig. 5. A rigid HGF II stabilizes the interaction between c-MET II and HGF I.

Fig. 5

a 3D reconstruction of the c-MET II/HGF I bound with an HGF II with rigid conformation, and the corresponding ribbon representation of this complex fitted into the cryo-EM map at 4.9 Å resolution, shown in two orthogonal views. b The ribbon representation of c-MET II/HGF I in complex with a complete version of HGF II shown in two orthogonal views. The model of the intact HGF II is also shown as surface representation. c Detailed view of heparin-binding at the N domains of HGF I and II. A long heparin polymer could mediate the interaction between HGF I and II. The heparin molecules are shown as surface representation.