Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 1;11:13694. doi: 10.1038/s41598-021-93014-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

EA at LI4 and LI11 acupoints prevents cocaine-induced CPP reinstatement in mice. (A) Timeline for the CPP testing, training, cocaine administration, and experimental interventions. (B) CPP scores for the CO group, CO + EA group, CO + MA group, and CO + LIDO + EA group, obtained during PRE, POST, EXT, and REIN testing. All data are expressed as the means ± S.E.M. (n = 7 mice per group). *p < 0.05; **p < 0.01 versus the PRE phases; ^&p < 0.05 versus the REIN phases; ^##p < 0.01 versus the CO group; ⁺⁺p < 0.01 versus the EA group (two-way ANOVA with the LSD post-hoc test). Abbreviations: CPP = Cocaine-induced conditioned place preference; PRE = Preconditioning testing; POST = Post-conditioning testing; EXT = Extinction of cocaine CPP testing; REIN = Cocaine-primed reinstatement testing; CO = No intervention; CO + EA = EA treatment; CO + MA = MA treatment; CO + LIDO + EA = Lidocaine (2%, 10 μL) injection followed by EA treatment.