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. 2021 Jul 1;11:13694. doi: 10.1038/s41598-021-93014-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagram showing synaptic events that occur after exposure to cocaine and subsequent events occurring in the NAc. (A) Cocaine upregulates levels of ΔFosB and GluR2 expression in the NAc. Chronic cocaine increases dendritic spine density in the NAc. (B) EA at LI4 and L11 reverses cocaine-induced changes in levels of ΔFosB and GluR2 expression in the NAc and also reverses the increases in dendritic spine density.