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. 2021 Jul 1;11:13674. doi: 10.1038/s41598-021-93256-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Renal capsule assays using lateral mandibles from E10 Runx2-KO mice. (A-a) Renal capsule assay of lateral mandibles from E10 Runx2-KO mice. At 19 days post-transplantation, no growth of transplanted mandibles and flattened explants were observed. *Agarose agar. (A-b) Renal capsule assay of lateral mandibles from E10 Runx2-KO mice. Transplantation was performed beneath the kidney capsule of nude mice (KSN/Slc) together with a cationized gelatin sheet containing Usag-1 siRNA #304. White tissue was attached underneath the renal capsule after 19 days. (A-c) 3D micro-CT image of the tissue shown in panel 4A-b. Mineralized hard tissue, such as bone, dentin, or enamel, was not observed. (B) We performed renal capsule transplantation of mandibles from Runx2-KO mice, alone or with cationized gelatin containing PBS or Usag-1 siRNA (#304 and #903). The percentage of growing explants formed in renal capsule grafts 19 days post-transplantation was calculated by dividing the number of growing explants by the number of Runx2-KO mouse mandibles transplanted.