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. 2021 Jul 2;54(8):1841–1852.e4. doi: 10.1016/j.immuni.2021.06.015

Figure 2.

Figure 2

Longitudinal decay in neutralizing antibody titers but increase in neutralizing potency index of RBD antibodies

(A) Timeline of sample collection for longitudinal analysis: mild (n = 67 from 28 individuals), moderate (n = 144 from 60 individuals), and severe (n = 78 from 32 individuals). Timing and number of samplings are indicated as line-connected circles; first (T1, light blue), second (T2, yellow), and third (T3, pink).

(B and C) Decay analysis of RBD IgG titers (B) and pseudovirus NT titers (C) from mild (green; n = 24 for T1–T2 and n = 15 for T2–T3), moderate (blue; n = 40 for T1–T2 and n = 44 for T2–T3), and severe (red; n = 21 for T1–T2 and n = 25 for T2–T3) groups. Bars represent the mean. Time points are within the following range of days after symptom onset: T1, 1–2 months; T2, 2–4 months; and T3, 5–7 months. Statistical significance is indicated as follows: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001 (Kruskal-Wallis test).

(D–F) Longitudinal neutralization potency index (NPI) and decay analysis of mild (D), moderate (E), and severe (F) groups. Data from the same individual are connected with lines in left panels. Bars represent the mean in right panels. Statistical significance is indicated as follows: ∗∗p < 0.01 and ∗∗∗p < 0.001 (Mann-Whitney test).