REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
M5E2 (V500) [anti-CD14]	BD Biosciences	561391 (RRID:AB_10611856)
HIB19 (V500) [anti-CD19]	BD Biosciences	561121 (RRID:AB_10562391)
RPA-T4 (BV605) [anti-CD4]	BD Biosciences	562989 (RRID:AB_2737935)
RPA-T8 (BV650) [anti-CD8]	BioLegend	301042 (RRID:AB_2563505)
RPA-T8 (BUV496) [anti-CD8]	BD Biosciences	612942 (RRID:AB_2870223)
FN50 (PE) [anti-CD69]	BD Biosciences	555531 (RRID:AB_2737680)
Ber-ACT35 (PE-Cy7) [anti-OX40]	Biolegend	350012 (RRID:AB_10901161)
4B4-1 (APC) [anti-CD137]	BioLegend	309810 (RRID:AB_830672)
OKT3 (AF700) [anti-CD3]	Biolegend	317340 (RRID:AB_2563408)
UCHT1 (BUV805) [anti-CD3]	BD Biosciences	612895 (RRID:AB_2870183)
HI100 (BV421) [anti-CD45RA]	Biolegend	304130 (RRID:AB_10965547)
G043H7 (FITC) [anti-CCR7]	Biolegend	353216 (RRID:AB_10916386)
Biological samples
Convalescent donor blood samples	UC San Diego Health	https://health.ucsd.edu/Pages/default.aspx
Convalescent donor blood samples	La Jolla Institute	https://www.lji.org
Convalescent donor blood samples	BioIVT	https://bioivt.com
COVID-19 vaccinee donor blood samples	La Jolla Institute	https://www.lji.org
Unexposed donor blood samples	San Diego Blood Bank	https://www.sandiegobloodbank.org
Unexposed donor blood samples	La Jolla Institute	https://www.lji.org
Unexposed donor blood samples	Carter Blood Care	https://www.carterbloodcare.org
Chemicals, peptides, and recombinant proteins
Synthetic peptides	TC Peptide Lab	https://tcpeptidelab.com
SARS-CoV-2 Receptor Binding Domain (RBD) protein	Stadlbauer et al.75	N/A
Deposited data
Ancestral	https://www.ncbi.nlm.nih.gov	NC_045512.2
B.1.1.7	https://www.GISAID.org	EPI_ISL_601443
B.1.351	https://www.GISAID.org	EPI_ISL_660629
B.1.351	https://www.GISAID.org	EPI_ISL_736930
B.1.351	https://www.GISAID.org	EPI_ISL_736932
B.1.351	https://www.GISAID.org	EPI_ISL_736944
B.1.351	https://www.GISAID.org	EPI_ISL_736971
B.1.351	https://www.GISAID.org	EPI_ISL_736966
B.1.351	https://www.GISAID.org	EPI_ISL_736973
B.1.351	https://www.GISAID.org	EPI_ISL_825104
B.1.351	https://www.GISAID.org	EPI_ISL_825120
B.1.351	https://www.GISAID.org	EPI_ISL_825131
P.1	https://www.GISAID.org	EPI_ISL_804823
CAL.20C	https://www.GISAID.org	EPI_ISL_847619
CAL.20C	https://www.GISAID.org	EPI_ISL_847621
CAL.20C	https://www.GISAID.org	EPI_ISL_847643
Software and algorithms
IEDB	Vita et al.76	https://www.iedb.org
IEDB-AR (analysis resource)	Reynisson et al.55	http://tools.iedb.org/main
NetMHCpan BA 4.1	Jurtz et al.77	http://tools.iedb.org/mhci/
VIGOR4	Pickett et al.78	https://www.viprbrc.org//brc/home.spg?decorator=vipr
FlowJo 10	FlowJo, LLC	https://www.flowjo.com
GraphPad Prism 8.4	GraphPad	https://www.graphpad.com