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. 2021 Jun 18;8:655639. doi: 10.3389/fmed.2021.655639

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Copyright © 2021 Li, Shen, Li, Leung, Zhu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) UMAP plot from unsupervised clustering of 23,980 cells from kidney cortex of healthy subjects and patients with diabetic nephropathy. (B) Expression levels of representative genes from each cluster. (C) UMAP plot of the two subclusters of glomerular endothelial cells. (D) Heatmap of top 30 up- and down-regulated DEGs in GEC0. (E) Heatmap of top 30 up- and down-regulated DEGs of GEC1. (F) Pie chart of significantly enriched GO terms group of GEC1. (G) UMAP plot of podocytes in healthy and diabetic conditions. (H) Heatmap of DEGs of podocytes. (I) UMAP plot of the two subclusters of mesangial cells. (J) Heatmap of top 30 up- and down-regulated DEGs in MC0. (K) Heatmap of top 30 up- and down-regulated DEGs in MC1. (L) Pie chart of significantly enriched GO terms group from DEGs of MC1. P-value < 0.05 were considered statistically different.